Insuline resistance

Insulin resistance treatment. Effect of diet and physical exercise treatment on insulin resistance syndrome of schoolchildren.

Whereas type 1 insulin resistance treatment is caused by an autoimmune response directed against the insulin-producing beta islet cells of the pancreas, type 2 insulin resistance treatment is caused by exhausting those beta cells through excessive energy consumption. Essentially, if one eats too much and has high blood glucose levels, the beta cells have to produce more and more insulin to keep up, eventually leading to accumulation insulin resistance treatment damage and death.

This state is referred to as insulin resistance, and it is considered to be a major contributor to the further development of type 2 diabetes.

Effect of diet and physical exercise treatment on insulin resistance syndrome of schoolchildren.

A major problem encountered by scientists seeking to study obesity and diabetes is that treatments developed in mice have failed to have any impact on humans, underlying their limited utility as a model organism for the disease. Given this stumbling block, researchers have increasingly begun to study other animals, as in a recent paper that focused on grizzly bears.

What is insulin resistance (and why does it occur)?

During the months leading up to hibernation, they are capable of doubling their levels of body fat. Such massive weight gain would result in serious health problems for humans, but bears are capable of tolerating these fluctuations, leading the authors to investigate how exactly this was possible.

insulin resistance treatment

As it turns out, bears are capable of uniquely regulating a protein called PTEN phosphatase and tensin homologwhich has a role in shutting off insulin signaling among other things. During the fall, while bears are bulking up, they turn off PTEN, which results in increased insulin sensitivity and insulin resistance treatment blood sugar levels despite weight gain.

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While hibernating, PTEN is turned back on, making the bears more insulin resistant and slowing weight loss during their long winter snooze. These findings with PTEN actually mirror a previous study insulin resistance treatment humans, in which patients who only had one copy of PTEN instead of two were more resistant to complications associated with weight gain, namely diabetes and heart disease.

Insuline resistance

So all we have to do is turn off PTEN in people and their type 2 diabetes will go away, right? Remember how PTEN does more than simply shutting down insulin signaling?

insulin resistance treatment

Well, one of those things is kind of important: It prevents cancer. PTEN is an essential tumor suppressor that has been implicated in dozens of malignancies. Indeed, those patients who lacked one copy of PTEN were found to develop aggressive cancers at a much higher rate than normal.

insulin resistance treatment

Though this may be potentially circumvented by targeting PTEN in fat cells only, it is still obviously a major concern for therapeutic development. While diabetes is certainly a cause of reduced quality of life, making patients more insulin sensitive will also result in increased weight gain.

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Since the obesity epidemic shows no signs of slackingaddressing the associated comorbidities is a major priority for biomedical researchers. And while this research is certainly promising, there are significant barriers that need to be overcome before a drug can even begin to be conceptualized.

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